1.
Alternative splicing and genome complexity.
Brett D, Pospisil H, Valcárcel J,
Reich J,
Bork PNat Genet.
2002 Jan; 30(1): 29-30. Epub 2001 Dec 17; PubMed:
11743582.Abstract + PDF
Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.