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Alcohol-Related Liver Disease Disrupts Bile Acid Homeostasis and Gut Microbial Bile Acid Metabolism.
Keller MI, de Zawadzki A, Thiele M, Suvitaival T, Sulek K,
Kuhn M,
Schudoma C,
Podlesny D,
Nishijima S,
Fullam A,
Kim CY, Niu L, Wretlind A, Hansen JK, Israelsen M, Johansen S,
Akanni W, Hazenbrink D, Juel HB, Mann M, Hansen T, Krag A,
Bork P, Legido-Quigley C, GALAXY & MicrobLiver consortia
Alcohol overuse disrupts liver function and alters gut microbial communities, with alcohol-related liver disease (ALD) causing half of all liver-related deaths worldwide. Bile acids (BAs) regulate liver and gut function, but their homeostasis becomes disrupted in ALD. Gut microbes transform primary BAs to secondary BAs, which are reabsorbed via enterohepatic circulation, but BA metabolism during ALD progression remains poorly understood.